On January 4th, 2006, His Highness Sheikh Mohammed bin Rashid Al Maktoum became the Ruler of Dubai following the death of his brother Sheikh Maktoum bin Rashid Al Maktoum.

On January 5th, the members of the Federal Supreme Council elected Sheikh Mohammed bin Rashid as the UAE’s Vice President. The UAE President His Highness Sheikh Khalifa bin Zayed Al Nahyan nominated Sheikh Mohammed to serve as the Prime Minister and form a new government, and the members of the Supreme Council approved the nomination.
On February 11th, 2006, His Highness Sheikh Mohammed bin Rashid and the members of the new Cabinet took oath of office before His Highness Sheikh Khalifa bin Zayed Al Nahyan at Al Bateen Palace in Abu Dhabi.

Since taking office as the Vice President and Prime Minister of the UAE and Ruler of Dubai, His Highness Sheikh Mohammed bin Rashid has overseen launching a raft of revolutionary initiatives in the UAE.

The year 2007 witnessed unique achievements for His Highness Sheikh Mohammed bin Rashid at the local and regional levels. On April 17th, 2007, His Highness unveiled the UAE Government Strategy aiming to achieve sustainable development across the UAE, utilize federal resources more effectively, and ensure accountability and transparency across federal entities.

In 2010, the UAE government launched the UAE Vision 2021, which charts the next stage of the UAE's journey leading up to the year 2021, and aims to make the UAE among the best countries in the world by the Golden Jubilee of the Union in 2021.

In 2014, His Highness Sheikh Mohammed bin Rashid Al Maktoum launched a seven-year National Agenda in order to guide efforts towards Vision 2021.
Noting the importance of investing in the future generations, by preparing them with the skills and knowledge needed to keep pace with rapid changes and to make the UAE the best country in the world by 2071, His Highness launched the UAE Centennial 2071, which is a long-term, full-vision plan that extends for 5 decades after 2021. It forms a clear map for the long-term government work, in order to strengthen the UAE’s reputation and its soft power.

Under the leadership of His Highness Sheikh Mohammed bin Rashid Al Maktoum, the UAE Cabinet underwent 14 reshuffles to keep pace with the changes and latest developments, which reflects the government's flexibility in keeping pace with national priorities and future trends.

During the second half 0f 2021, His Highness Sheikh Mohammed bin Rashid Al Maktoum announced a new strategy for federal government work to accelerate achievements and set priorities. His Highness also directed all government institutions to adopt and implement the UAE’s 10 “Principles of the 50”, approved by His Highness the President of the UAE, while developing plans and strategies.

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